FRI 7 In-vitro evaluation of thermal dose accuracy for high intensity focused ultrasound hyperthermia therapy: MRgFUS experience
نویسندگان
چکیده
High intensity focused ultrasound (HIFU) has performed its non-invasive heating capability for tumour treatment. Magnetic resonance image (MRI) guided HIFU surgery has been initially proved for uterine fibroid. ExAblate MRgFUS system (Insightec, Israel) recently demonstrated hyperthermia application for malignant bone metastasis palliation and been certificated by US FDA. HIFU beam projects ultrasound power at precise local bone cortex. In order to protect nearby critical organs, thermal dose should be delivered correctly to treatment area within a short period. Over 56°C/sec heat shock theoretically creates thermo necrosis in human tissue. MRgFUS system embedded proton resonance frequency (PRF) algorithm to monitor real time temperatures. Hence, we reported heating calibration protocols and thermal dose, which integrates true temperature measurement and PRF readout at target spots.
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